A lot of principles illustrated in the book is not only about how we deal with digital information, but also how we deal with our relationships with this increasingly complex world and with each other (often we don't even see each other anymore).
A very important message for designers in this book is that we have to be cautious with everything we make — even just a piece of graphic or a blog post — because once it gets into the world of information, it cause consequences that we may not expect.